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KMID : 1377020130100060329
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Tissue Engineering and Regenerative Medicine
2013 Volume.10 No. 6 p.329 ~ p.335
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Intra-articular injections of platelet-rich plasma in patients with knee pain of articular cartilage origin (degenerative chondropathy and early OA)
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Lee Kyo-Sun
Asode Ananthram Shetty
Kim Seok-Jung
Kim Young-Ju
Jun Young-Joon
Choi Nam-Yong
Park Gi-Beom
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Abstract
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Platelet-rich plasma (PRP) has been used as an alternative to non-operative treatments for increasing the rate of cure in bone and soft-tissue regeneration, although there are very few clinical studies regarding the treatment of articular cartilage damage. Therefore, our study proposes non-surgical intervention for patients with articular cartilage damage and who are experiencing knee pain caused by this damage. This study was conducted as a single medical center. It was an uncontrolled, prospective clinical trial, and the study subjects included 44 patients who were suffering from early osteoarthritis and degenerative chondropathy; they were between 18 and 65 years of age and were included in the study irregardless their sex. PRP was injected twice intraarticulary within an interval of four weeks. The pain scores and functional scores were compared two months, four months, and six months following the second injection was completed, using the VAS, the Lysholm knee scale, and the Cincinnati knee rating system. There were no complications related to the PRP injection. The pain experienced by the study patients two months after the PRP injection was reduced compared to the pain felt before the injection, and the reduction in pain after four and six months compared to the pain experienced two months after the PRP injection was statistically significant. From a functional viewpoint, there was a statistically significant improvement in their pain during the entire follow-up period. Our study results suggest that PRP injection is an effective and safe treatment for the management of early osteoarthritis and degenerative chondropathy, as seen in this clinical trial.
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KEYWORD
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platelet rich plasma, knee pain, early osteoarthritis, chondropathy
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